Application
Western blot analysis of TALL-1 expression in non-transfected: (A) and human TALL-1 transfected: (B) 293T whole cell lysates.Application
Immunofluorescence staining of normal mouse liver frozen section showing extracellular staining.| Product Name | TALL-1 Antibody (H-230) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 1-230 mapping at the N-terminus of TALL-1 of human origin |
| Modification Notes | TNF cytokine family member TALL-1 (also designated BAFF, THANK and BLyS), is a type II membrane protein that shares characteristics with other members of the tumor necrosis factor (TNF) cytokine family. TALL-1 is expressed abun-dantly in peripheral blood leukocytes, monocytes and macrophages. TALL-1 is critically involved in the regulation of infections, inflammation, autoimmune diseases and tissue homeostasis. TALL-1 is a potent B cell stimulatory factor which is functionally involved in B cell proliferation and may be a primary mediator in B cell-associated autoimmune diseases. The C-terminal extracellular domain has b jelly roll topography and is important in ligand trimerization. The binding of the ligand to its respective receptor induces oligomerization, initiating downstream signaling events. Intrinsic to oligomerization is the formation of the receptor binding site at the junction between neighboring subunits, creating a multivalent ligand. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of TALL-1 of mouse, rat and human origin by WB, IP, IF and ELISA: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 1-230 mapping at the N-terminus of TALL-1 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 1-230 mapping at the N-terminus of TALL-1 of human origin |
| Entrez Gene | 10673 |
|---|
Application
Western blot analysis of TALL-1 expression in non-transfected: (A) and human TALL-1 transfected: (B) 293T whole cell lysates.
Application
Immunofluorescence staining of normal mouse liver frozen section showing extracellular staining.| Application Notes | recommended for detection of TALL-1 of mouse, rat and human origin by WB, IP, IF and ELISA: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
