Application
Western blot analysis of NDUFV2 expression in non-transfected 293T: (A), human NDUFV2 transfected 293T: (B), HeLa (C) and NIH/3T3 (D) whole cell lysates.Application
Western blot analysis of NDUFV2 expression in non-transfected 293T: (A), mouse NDUFV2 transfected 293T: (B) and Ramos (C) whole cell lysates.| Product Name | NDUFV2 Antibody (FL-249) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 1-249 representing full length NDUFV2 of human origin |
| Modification Notes | Located in the mitochondrial inner membrane, mitochondrial complex I is the first and largest enzyme in the electron transport chain of oxidative phosphorylation. By oxidizing NADH that is produced in the Krebs cycle, this complex utilizes the two electrons to reduce ubiquinone to ubiquinol, thereby initiating the passage of electrons to successive complexes and ultimately leading to the reduction of oxygen to water. Mitochondrial complex I consists of over 40 subunits and is of considerable clinical interest since defects in any one of the subunits can lead to various myopathies and neuropathies. As a subunit of mitochondrial complex I, NDUFV2 (NADH dehydrogenase [ubiquinone] flavoprotein 2), also designated NADH-ubiquinone oxidoreductase 24 kDa subunit, is a 249 amino acid protein that is believed to be required for catalytic activity. Several studies suggest that polymorphisms of the gene encoding NDUFV2 may be a genetic risk factor for bipolar disorder and schizophrenia. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of NDUFV2 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including canine, bovine and porcine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 1-249 representing full length NDUFV2 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 1-249 representing full length NDUFV2 of human origin |
| Entrez Gene | 4729 |
|---|
Application
Western blot analysis of NDUFV2 expression in non-transfected 293T: (A), human NDUFV2 transfected 293T: (B), HeLa (C) and NIH/3T3 (D) whole cell lysates.
Application
Western blot analysis of NDUFV2 expression in non-transfected 293T: (A), mouse NDUFV2 transfected 293T: (B) and Ramos (C) whole cell lysates.| Application Notes | recommended for detection of NDUFV2 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including canine, bovine and porcine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
