| Modification Notes |
∫-defensins (also designated BDs, or hBDs in human) are small cationic peptides with broad-spectrum antimicrobial activity against a variety of enveloped viruses, fungi and bacteria. Produced in mucosal epithelia and neutrophils of several species, ∫-defensins are developmentally regulated. The family of ∫-defensin proteins share a common defensin-motif that is characterized by multiple cysteine residues and a highly conserved tertiary structure. Besides playing a significant role in host immune defense, many ∫-defensins are also involved in sperm maturation and capacitation. ∫-defensin 135, also designated ∫-defensin 136, is a 77 amino acid member of the ∫-defensin protein family. ∫-defensin 135 is a secreted protein believed to have antibacterial activity. |