| Modification Notes |
SNRPC (small nuclear ribonucleoprotein polypeptide C) is a 159 amino acid protein that localizes to the nucleus and contains one matrin-type zinc finger. Existing as a monomer, SNRPC associates with U1 SnRNP 70 and may play a role in ribonucleoprotein-related events. The gene encoding SNRPC maps to human chromosome 6, which contains 170 million base pairs and comprises nearly 6% of the human genome. Deletion of a portion of the q arm of chromosome 6 is associated with early onset intestinal cancer, suggesting the presence of a cancer susceptibility locus. Additionally, Porphyria cutanea tarda, Parkinson's disease, Stickler syndrome and a susceptibility to bipolar disorder are all associated with genes that map to chromosome 6. |