| Modification Notes |
Olfactorin, also known as UMODL1 (uromodulin-like 1), is a 1,318 amino acid single-pass type I membrane protein that localizes to both the cell membrane and the cytoplasm. Expressed as four tissue-specific isoforms (isoform 3 is present in testis, prostate and fetal thymus, while isoforms 4 is present in kidney and testis), Olfactorin is thought to play a role in the maturation of the olfactory system and may participate in developmental neurobiology events. Olfactorin contains several functional domains, including one ZP domain, one WAP domain, one EMI domain, two SEA domains, two fibronectin type-III domains and three EGF-like domains. Defects in the gene encoding Olfactorin may contribute to an increased susceptibility for high myopia, a degenerative condition that effects overall eye structure and vision. |