Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. The majority of zinc-finger proteins contain Krüppel-type DNA binding domains that are frequently observed to be involved in sequence-specific DNA binding. ZNF550 is a 442 amino acid transcriptional regulator belonging to the Krüppel C2H2-type zinc-finger protein family. ZNF550 localizes to the nucleus and contains 8 C2H2-type zinc fingers and a KRAB domain. Two isoforms of ZNF550 are formed due to alternative splicing. ZNF550 is encoded by a gene located on chromosome 19, which contains a diversity of interesting genes and is recognized for having the greatest gene density of the human chromosomes. chromosome 19 is the genetic home for a number of immunoglobulin superfamily members, including the killer cell and leukocyte Ig-like receptors, a number of ICAMs, the CEACAM and PSG family and Fc receptors (FcR). Key genes for eye color and hair color also map to chromosome 19.
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested Applications
WBIPELISA
recommended for detection of ZNF550 of human and canine origin by WB, IP and ELISA: