Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. The majority of zinc-finger proteins contain a Krüppel-type DNA binding domain and a KRAB domain, which is thought to interact with KAP1, thereby recruiting histone modifying proteins. Zinc finger protein 175 (ZNF175), also known as OTK18, is a 711 amino acid member of the Krüppel C2H2-type zinc-finger protein family. Localized both to the nucleus and cytosol, ZNF175 contains 15 C2H2-type zinc fingers and 1 KRAB domain. Induced by HIV-1 infection, ZNF175 is thought to be an HIV-1-inducible transcriptional suppressor.
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested Applications
WBIPELISA
recommended for detection of ZNF175 of human origin by WB, IP and ELISA