The RING-type zinc finger motif is present in a number of viral and eukaryotic proteins and is made of a conserved cysteine-rich domain that is able to bind two zinc atoms. Proteins that contain this conserved domain are generally involved in the ubiquitination pathway of protein degradation. RNF38 (RING finger protein 38) is a 515 amino acid protein that contains one RING-type zinc finger through which it may play a role in transcriptional regulation and protein degradation events. Defects in the gene encoding RNF38 are associated with a variety of disorders, including acromesomelic dysplasia (AMDM), arthrogryposis distal multiplex congenita type 1 (AMCD1) and autosomal recessive ataxic cerebral palsy (ACP), as well as various malignancies. Two isoforms of RNF38 are expressed due to alternative splicing events.
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested Applications
WBIPELISA
recommended for detection of RNF38 of human origin by WB, IP and ELISA: