Application
Western blot analysis of MMP-21 expression in non-transfected: (A) and human MMP-21 transfected: (B) 293T whole cell lysates.| Product Name | MMP-21 Antibody (H-225) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 301-525 mapping near the C-terminus of MMP-21 of human origin |
| Modification Notes | The matrix metalloproteinases (MMPs) are a family of peptidase enzymes responsible for the degradation of extracellular matrix components, including collagen, gelatin, fibronectin, laminin and proteoglycan. Transcription of MMP genes is differentially activated by phorbol ester, lipopolysaccharide (LPS) or staphylococcal enterotoxin B (SEB). MMP catalysis requires both calcium and zinc. MMP-21 is 569 amino acid residues in length and consists of a prodomain, catalytic domain, and haemopexin-like domain. It is the human orthologue for XMMP in X. laevis and CyMMP in C. pyrrhogaster. MMP-21 is expressed in various fetal and adult tissues. It a possible target gene of the Wnt pathway, and the expression of this protein is controlled by Pax and Notch transcription factors. MMP-21 may play an important role in embryogenesis, tissue development (particularly in the brain), tumor progression and possibly apoptosis. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of MMP-21 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine and canine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 301-525 mapping near the C-terminus of MMP-21 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 301-525 mapping near the C-terminus of MMP-21 of human origin |
| Entrez Gene | 118856 |
|---|
Application
Western blot analysis of MMP-21 expression in non-transfected: (A) and human MMP-21 transfected: (B) 293T whole cell lysates.| Application Notes | recommended for detection of MMP-21 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine and canine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
