| Product Name | plexin-D1 Antibody (H-70) |
|---|---|
| Antibody Type | Primary Antibodies |
| Modification Notes | Plexins are a family of large transmembrane receptors for multiple classes of semaphorins. Plexins are widely expressed and may act as semaphorin receptors alone or in combination with neuropilins. Plexins are divided into four subfamilies, plexin-A, -B, -C and -D. Plexin-D1 is expressed strongly in endothelial cells of developing blood vessels and in lower levels in placenta, heart, brain, kidney, testis and lung. Expression is more robust in mouse and human embryonic cells than in adult cells, and the protein is detected in early ganglia, cortex and striatum. The gene PLXND1, which encodes for the protein, localizes to chromosome 3q21.3. A defect in this gene causes the dominantly inherited disorder Möbius syndrome 2 (MBS2) which is characterized by paralysis of the facial nerve. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of plexin-D1 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including canine, bovine and porcine | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 211-280 mapping within an N-terminal extracellular domain of plexin-D1 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 211-280 mapping within an N-terminal extracellular domain of plexin-D1 of human origin |
| Entrez Gene | 23129 |
|---|
| Application Notes | recommended for detection of plexin-D1 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including canine, bovine and porcine |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
