Application
Immunofluorescence staining of methanol-fixed NIH/3T3 cells showing nuclear localization.| Product Name | NALP1 Antibody (M-90) |
|---|---|
| Antibody Type | Primary Antibodies |
| Modification Notes | NACHT-, LRR- and PYD-containing protein 1 (NALP1), also designated caspase recruitment domain protein 7, is a cytoplasmic protein. NALP1 contains a putative nucleotide binding site, a region of leucine-rich repeats and death domain folds at both termini, providing protein/protein association functions such as caspase recruitment. NALP1 is involved in the innate immune response and is a component of the inflammasome. It forms cytoplasmic structures called death effector filaments and enhances APAF1 and cytochrome c-dependent activation of pro-caspase-9 and consecutive apoptosis. NALP1 is widely expressed in thymus, heart, spleen and peripheral blood leukocytes. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | ELISAIFIPWB |
| WB:1:100~1:500 IP:1:20~1:100 IF:1:20~1:100 |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 181-270 mapping within an internal region of NALP1a of mouse origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 181-270 mapping within an internal region of NALP1a of mouse origin |
| Entrez Gene | 195046 |
|---|
Application
Immunofluorescence staining of methanol-fixed NIH/3T3 cells showing nuclear localization.| Application Notes | WB:1:100~1:500 IP:1:20~1:100 IF:1:20~1:100 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
