Application
Western blot analysis of CLCA1 expression in mouse liver tissue extract.| Product Name | CLCA1 Antibody (H-54) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 861-914 mapping at the C-terminus of CLCA1 of human origin |
| Modification Notes | The calcium-activated chloride channel (CLCA) protein family, which includes the human homologs CLCA1 and CLCA2, display distinct tissue distribution patterns. CLCA1 is expressed as a precursor protein that is processed into two cell surface associated subunits and a group of proteins. CLCA1 is upregulated by interleukin-9 and regulates the expression of mucins. CLCA1 may provide a therapeutic target to control mucus overproduction in airway disease patients with cystic fibrosis. CLCA2 expression is downregulated in breast cancer and therefore, is thought to act as a tumor suppressor in normal cells. CLCA3 is a structurally divergent member of the CLCA family that does not function as a channel protein. CLCA4 is a CLCA member that is expressed in human rectal mucosa, CLCA5 shows strong expression in eye and spleen, and CLCA6 is primarily expressed in intestine and stomach. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of CLCA1 of human and, to a lesser extent, mouse origin by WB, IP, IF and ELISA: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 861-914 mapping at the C-terminus of CLCA1 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 861-914 mapping at the C-terminus of CLCA1 of human origin |
| Entrez Gene | 1179 |
|---|
Application
Western blot analysis of CLCA1 expression in mouse liver tissue extract.| Application Notes | recommended for detection of CLCA1 of human and, to a lesser extent, mouse origin by WB, IP, IF and ELISA: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
