| Product Name | BBS6 Antibody (H-300) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 271-570 mapping at the C-terminus of BBS6 of human origin |
| Modification Notes | Bardet-Biedl syndrome (BBS) is a pleiotropic genetic disorder characterized by obesity, photoreceptor degeneration, polydactyly, hypogenitalism, renal abnormalities, and developmental delay. BBS patients also have an increased risk of developing diabetes, hypertension, and congenital heart defects. BBS is a heterogeneous disorder; BBS genes map to eight genetic loci and encode eight proteins, BBS1-BBS8. Five BBS genes encode basal body or cilia proteins, suggesting that BBS is a ciliary dysfunction disorder. BBS6 is a Group II chaperonin-like protein that has evolved recently in animals from CCT/TRiC, a subunit of the eukaryotic chaperonin. Most of BBS6 localizes to the pericentriolar material (PCM), a proteinaceous tube surrounding centrioles. During interphase, BBS6 is restricted to the lateral surfaces of the PCM, but during mitosis, it relocalizes throughout the PCM and localizes to the intercellular bridge. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of BBS6 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including canine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 271-570 mapping at the C-terminus of BBS6 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 271-570 mapping at the C-terminus of BBS6 of human origin |
| Application Notes | recommended for detection of BBS6 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including canine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
