| Product Name | EULIR Antibody (H-300) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 1-300 mapping at the N-terminus of EULIR of human origin |
| Modification Notes | EULIR (E3 ubiquitin-protein ligase for inhibin receptor), also known as HECTD1, functions as an E3 ubiquitin ligase. As such, EULIR is a major component of the ubiquitin-proteasome system and plays a role in determining the specificity of ubiquitin conjugation. It is responsible for transferring ubiquitin to targeted substrates from an E2 ubiquitin-conjugating enzyme through the intermediate formation of a thiol ester with ubiquitin. Similar to a number of other E3 ubiquitin ligases, EULIR contains an N-terminal ankyrin repeat domain, a mind bomb (mib) domain and a C-terminal HECT (homologous to E6-AP C-terminus) domain. The HECT domain is responsible for the ubiquitin ligase activity, catalyzing polyubiquitination. EULIR is ubiquitously expressed throughout early development and is important for the complete and proper closure of the neural tube. Mutations in the gene encoding EULIR can result in neural tube defects. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of EULIR of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine, porcine and avian: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 1-300 mapping at the N-terminus of EULIR of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 1-300 mapping at the N-terminus of EULIR of human origin |
| Entrez Gene | 25831 |
|---|
| Application Notes | recommended for detection of EULIR of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine, porcine and avian: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
