Application
Western blot analysis of LAPSER1 expression in non-transfected: (A) and human LAPSER1 transfected: (B) 293T whole cell lysates.| Product Name | LAPSER1 Antibody (H-98) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 459-556 mapping near the C-terminus of LAPSER1 of human origin |
| Modification Notes | LAPSER1, also called Leucine zipper putative tumor suppressor 2, is a member of the LZTS family. Due to its deletion in multiple cancers, including prostate tumors, LAPSER1 is purported to be a tumor suppressor. In cancer cell lines, the overexpression of LAPSER1 can lead to growth inhibition and colony-forming efficiency. LAPSER1 is highly expressed in testis and prostate, but can be detected at lower levels in spleen, thymus, uterus, small intestine and colon. LAPSER1 colocalizes with ©-tubulin, MKLP-1 and p80 katanin. LAPSER1 is involved in cytokinesis. The disruption of LAPSER1, which is accompanied by the mislocalization of p80 katanin, results in malformation of the central spindle. This is a potential impetus for carcinogenesis. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of LAPSER1 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine and bovine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 459-556 mapping near the C-terminus of LAPSER1 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 459-556 mapping near the C-terminus of LAPSER1 of human origin |
| Entrez Gene | 84445 |
|---|
Application
Western blot analysis of LAPSER1 expression in non-transfected: (A) and human LAPSER1 transfected: (B) 293T whole cell lysates.| Application Notes | recommended for detection of LAPSER1 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine and bovine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
