| Product Name | SDHD Antibody (FL-159) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 1-159 representing full length SDHD of human origin |
| Modification Notes | Succinate dehydrogenase is a membrane-bound enzyme complex that localizes to the inner mitochondrial membrane and functions in both the citric acid cycle and the electron transport chain. It is found in several aerobic and anaerobic organisms, including Escherichia coli. Succinate dehydrogenase is a heterotetramer divided into three domains: SDHA, the catalytic domain; SDHB, the electron transfer subunit; SDHC/SDHD, the dimeric membrane anchor that contains ∫-type heme. Mutations in the gene encoding for SDHD are associated with hereditary paraganglioma, possibly through a mechanism that causes a hypoxic response in the cell that leads to tumor formation. SDHD mutation related tumors, which originate in the head and neck, are usually benign. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of SDHD of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including canine, bovine and porcine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 1-159 representing full length SDHD of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 1-159 representing full length SDHD of human origin |
| Entrez Gene | 6392 |
|---|
| Application Notes | recommended for detection of SDHD of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including canine, bovine and porcine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
