Application
Western blot analysis of MaxiKα expression in non-transfected (A) and human MaxiKα transfected (B) CMV whole cell lysates.| Product Name | MaxiKα Antibody (H-300) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 937-1236 mapping at the C-terminus of MaxiKα of human origin |
| Modification Notes | The KCNMA1 gene, located on chromosome 10q22.3, encodes MaxiKå (also designated calcium-activated potassium channel, large conductance calcium- and voltage-dependent potassium channel å subunit, Slo å subunit and BKCA å subunit). MaxiKå carboxyl terminal is spliced to form nine transcripts. MaxiKå is expressed in neurons and smooth muscle tissue. It associates with MaxiK∫ to form Ca2+-activated K+ channels (also designated Maxi-K or BK channels) and forms the potassium-permeable pore in these channels, which respond primarily to increases in intracellular calcium ion concentrations. Maxi-K channels are also known to interact with hormones, such as estradiol. MaxiK∫ can regulate the sensitivity of MaxiKå to calcium. Maxi-K channels may be involved in cell shrinkage and caspase activation, which leads to pulmonary vascular smooth muscle cell apoptosis. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of MaxiKα of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including bovine, porcine and avian: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 937-1236 mapping at the C-terminus of MaxiK&alpha of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 937-1236 mapping at the C-terminus of MaxiKα of human origin |
| Entrez Gene | 3778 |
|---|
Application
Western blot analysis of MaxiKα expression in non-transfected (A) and human MaxiKα transfected (B) CMV whole cell lysates.| Application Notes | recommended for detection of MaxiKα of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including bovine, porcine and avian: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
