| Modification Notes |
AQP6 (also designated AQP2L) is a 282 amino acid protein that localizes to intracellular membranes in renal epithelia. Aquaporins (AQPs) are a large family of integral membrane water transport channel proteins that facilitate the transport of water through the cell membrane. This function is conserved in animals, plants and bacteria. Many isoforms of aquaporin have been identified in mammals, designated AQP0 through AQP10. Aquaporins are widely distributed; it is not uncommon for more than one type of AQP to be present in the same cell. Although most aquaporins are permeable only to water, AQP3, AQP7, AQP9 and one of the two AQP10 transcripts are also permeable to urea and glycerol. Aquaporins are involved in renal water absorption, generation of pulmonary secretions, lacrimation and the secretion and reabsorption of cerebrospinal fluid and aqueous humor. AQP6 may contribute to glomerular filtration, tubular endocytosis and acid-base metabolism. |