| Product Name | NIS Antibody (H-42) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 11-52 mapping near the N-terminus of NIS of human origin |
| Modification Notes | The sodium/iodide symporter (NIS) is an integral plasma membrane glycoprotein that mediates active iodide transport in the thyroid and other tissues, including salivary glands, gastric mucosa, and lactating mammary gland. In the lactating mammary gland, NIS transports iodide into the milk, thereby allowing the nursing newborn to use the iodide for thyroid hormone biosynthesis. NIS is expressed in some breast cancers, but exhibits decreased expression in the majority of thyroid cancers, most likely due to alterations in the binding activity of AP2 and Sp1 transcription factors to the NIS promoter. NIS is a prerequisite for radioiodide treatment of thyroid cancer and a promising diagnostic and therapeutic tool for breast cancer. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of NIS of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including canine, bovine and porcine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 11-52 mapping near the N-terminus of NIS of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 11-52 mapping near the N-terminus of NIS of human origin |
| Application Notes | recommended for detection of NIS of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including canine, bovine and porcine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
