| Product Name | ME2 Antibody (G-17) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope mapping within an internal region of ME2 of human origin |
| Modification Notes | ME2, malic enzyme 2, is a mitochondrial NAD-dependent malic enzyme. Found as a homotetramer, the main function of ME2 is to catalyze the anaplerotic reaction yielding pyruvate from (s)-malate. One single-nucleotide polymorphism of the ME2 gene has been associated with a phenotype manifested as psychosis. ME2 directly interacts with the malate shuttle system and has roles in neuronal synthesis of glutamate and gamma-amino butyric acid. This system has been shown to be altered in schizophrenia and bipolar disorder, which is also characterized by forms of epilepsy brought on by the role ME2 on ion channels in the brain. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIFELISA |
| recommended for detection of ME2 of mouse, rat and human origin by WB, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope mapping within an internal region of ME2 of human origin |
|---|---|
| Tissue Specificity | epitope mapping within an internal region of ME2 of human origin |
| Entrez Gene | 4200 |
|---|
| Application Notes | recommended for detection of ME2 of mouse, rat and human origin by WB, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
