| Product Name | ASPM Antibody (H-141) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 790-930 mapping within an internal region of ASPM of human origin |
| Modification Notes | Microcephaly is a genetic disorder in which the affected individual has a head circumference less than three standard deviations below the sex- and age-related mean. The reason for the reduced head circumference is due to the formation of a small brain of normal proportions; all affected individuals are mentally retarded. ASPM (for abnormal spindle homolog, microcephaly associated), also designated microcephaly, primary autosomal recessive 5 (MCPH5), is caused by mutation in the ASPM gene. In a comprehensive mutation screen of the ASPM gene, 19 mutations were identified in a cohort of 23 consanguineous families. The mutations occur throughout the gene and are all assumed to be protein truncating. Research demonstrates that phenotypic variation in 51 affected individuals occurrs in the degree of microcephaly (5 to 11 SDs below normal) and of mental retardation (mild to severe), but appeared to be independent of mutation position in the gene. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of ASPM of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine, porcine and avian: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 790-930 mapping within an internal region of ASPM of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 790-930 mapping within an internal region of ASPM of human origin |
| Entrez Gene | 259266 |
|---|
| Application Notes | recommended for detection of ASPM of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine, porcine and avian: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
