| Product Name | PTPρ Antibody (H-66) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 25-90 mapping near the N-terminus of PTPρ of human origin |
| Modification Notes | Protein tyrosine phosphatases, or PTPs, are type I transmembrane proteins, membrane associated proteins or proteins localized in nuclei. Examples of transmembrane PTPs are LAR, PTPå, PTP∫, PTP©, PTP∂, PTPe, PTPΩ, PTP˚, PTPµ and PTPr. Transmembrane PTPs play diverse roles in a variety of cellular processes during development and in adult tissues. PTPr, also known as PTPRT, RPTPT or RPTPr, is a receptor-type PTP (RPTP) containing a transmembrane region, two intracellular tandem catalytic domains, an extracellular region with Ig-like and Fibronectin type III-like repeats and a MAM (meprin-A5 antigen-PTPµ) domain. RPTPs participate in neurite extension, signal transduction and cell adhesion. PTPr is expressed at high levels in the central nervous system of both developing and adult tissues. It interacts with a variety of proteins that function at intercellular adheren junctions and it specifically binds and dephosphorylates E-cadherin. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of PTPρ of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including canine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 25-90 mapping near the N-terminus of PTPρ of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 25-90 mapping near the N-terminus of PTPρ of human origin |
| Entrez Gene | 11122 |
|---|
| Application Notes | recommended for detection of PTPρ of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including canine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
