| Modification Notes |
The Fox family of transcription factors is a large group of proteins that share a common DNA-binding domain, termed a winged-helix or forkhead domain, and are classified into 20 subclasses. Many Fox proteins play important roles in development, metabolism, cancer and aging. FKHL18, also designated Forkhead box protein S1 (FoxS1) or Forkhead-related transcription factor 10 (FREAC-10), is a structurally unique member of the Fox family. FKHL18 is expressed in aorta, sensory neurons and fetal testis, suggesting diverse functions of the FKHL18 protein. Specifically, FKHL18 is thought to play a role in the integration and processing of neuronal signaling necessary for energy turnover and motor function. It has also been established as an early sensory neuronal marker. |