| Product Name | NUFIP1 Antibody (K-15) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope mapping within an internal region of NUFIP1 of human origin |
| Modification Notes | NUFIP1 (Nuclear fragile X mental retardation-interacting protein 1) is a 495 amino acid protein that localizes to the nucleus and can interact with FMR1 (fragile X mental retardation protein) and BRCA1, a breast and ovarian-specific tumor suppressor. Through its interaction with FMR1, NUFIP1 is thought to shuttle specific mRNPs to active neuronal synapses, thereby regulating the translation of synaptic plasticity-related mRNA. The close interaction of NUFIP1 with FMR1, a protein that is essential for proper dendritic spine maturation, suggests close involvement in neuronal development. Interaction of NUFIP1 with BRCA1 results in the formation of a complex which binds the positive elongation factor P-TEFb, thus stimulating RNA polymerase II (pol II) transcription. When associated with BRAC1, NUFIP1 acts as a transcriptional activator contributing to tumor suppressor gene expression. NUFIP1 contains 1 C2H2-type zinc finger and is expressed throughout the body. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIFELISA |
| recommended for detection of NUFIP1 of mouse, rat and human origin by WB, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope mapping within an internal region of NUFIP1 of human origin |
|---|---|
| Tissue Specificity | epitope mapping within an internal region of NUFIP1 of human origin |
| Entrez Gene | 26747 |
|---|
| Application Notes | recommended for detection of NUFIP1 of mouse, rat and human origin by WB, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
