| Product Name | TRABID Antibody (E-13) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope mapping within an internal region of TRABID of human origin |
| Modification Notes | TRABID (TRAF-binding domain-containing protein), also known as ZRANB1 (zinc finger Ran-binding domain-containing protein 1), is a 708 amino acid cytoplasmic and nuclear protein that is widely expressed. Belonging to the peptidase C64 family, TRABID is considered a positive regulator of the Wnt signaling pathway that specifically cleaves 'Lys-63'-linked ubiquitin chains. TRABID acts by deubiquitinating APC, a negative regulator of Wnt-mediated transcription. TRABID contains a OTU domain, which mediates the deubiquitinating activity, and three RanBP2-type zinc fingers that mediate the specific interaction with 'Lys-63'-linked ubiquitin. It is suggested that TRABID may also modulate TNFå signaling. The gene encoding TRABID is located on chromosome 10, which houses over 1,200 genes and comprises nearly 4.5% of the human genome. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIFELISA |
| recommended for detection of TRABID of mouse, rat and human origin by WB, IF and ELISA also reactive with additional species, including equine, canine, bovine, porcine and avian: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope mapping within an internal region of TRABID of human origin |
|---|---|
| Tissue Specificity | epitope mapping within an internal region of TRABID of human origin |
| Entrez Gene | 54764 |
|---|
| Application Notes | recommended for detection of TRABID of mouse, rat and human origin by WB, IF and ELISA also reactive with additional species, including equine, canine, bovine, porcine and avian: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
