| Product Name | IRF-2BP2 Antibody (L-13) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope mapping near the C-terminus of IRF-2BP2 of human origin |
| Modification Notes | Interferon regulatory factors-1 and -2 (IRF-1 and IRF-2) are DNA-binding proteins that function as regulators of both type I interferons (IFN-å and -∫) and interferon-inducible genes. IRF-2BP2 (interferon regulatory factor 2 binding protein 2) is a 587 amino acid nuclear protein that belongs to the IRF-2BP family and exists as part of a corepressor complex with IRF-1 and IRF-2BP1. Interacting with the C-terminal domain of IRF-2, IRF-2BP2 functions to repress transcription in an IRF-2-dependent manner. IRF-2BP2 is expressed as three alternatively spliced isoforms and is encoded by a gene that maps to human chromosome 1. Chromosome 1 is the largest human chromosome, spanning about 260 million base pairs and comprising 8% of the human genome. Several disorders, including Stickler syndrome, Parkinsons disease, Gaucher disease, malignant melanoma and Usher syndrome, are caused by defects chromosome 1-localized genes. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIFELISA |
| recommended for detection of IRF-2BP2 isoforms 1-3 of mouse and human origin by WB, IF and ELISA non cross-reactive with IRF-2BP1 family members: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope mapping near the C-terminus of IRF-2BP2 of human origin |
|---|---|
| Tissue Specificity | epitope mapping near the C-terminus of IRF-2BP2 of human origin |
| Entrez Gene | 359948 |
|---|
| Application Notes | recommended for detection of IRF-2BP2 isoforms 1-3 of mouse and human origin by WB, IF and ELISA non cross-reactive with IRF-2BP1 family members: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
