Application
Western blot analysis of CCDC57 expression in non-transfected: (A) and human CCDC57 transfected: (B) 293T whole cell lysates.| Product Name | CCDC57 Antibody (E-12) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope mapping within an internal region of CCDC57 of human origin |
| Modification Notes | The coiled-coil domain is a structural motif found in proteins that are involved in a diverse array of biological functions such as the regulation of gene expression, cell division, membrane fusion and drug extrusion and delivery. CCDC57 (coiled-coil domain containing 57) is a 916 amino acid protein that exists as two alternatively spliced isoforms. The gene encoding CCDC57 maps to human chromosome 17q25.3. Encoding over 1,200 genes, chromosome 17 comprises over 2.5% of the human genome. Two key tumor suppressor genes are associated with chromosome 17, namely, p53 and BRCA1. Tumor suppressor p53 is necessary for maintenance of cellular genetic integrity by moderating cell fate through DNA repair versus cell death. Malfunction or loss of p53 expression is associated with malignant cell growth and Li-Fraumeni syndrome. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of CCDC57 isoforms 1 and 2 of mouse, rat and human origin by WB, IP, IF and ELISA non cross-reactive with other CCDC family members: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope mapping within an internal region of CCDC57 of human origin |
|---|---|
| Tissue Specificity | epitope mapping within an internal region of CCDC57 of human origin |
| Entrez Gene | 284001 |
|---|
Application
Western blot analysis of CCDC57 expression in non-transfected: (A) and human CCDC57 transfected: (B) 293T whole cell lysates.| Application Notes | recommended for detection of CCDC57 isoforms 1 and 2 of mouse, rat and human origin by WB, IP, IF and ELISA non cross-reactive with other CCDC family members: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
