| Product Name | MCM10 Antibody (H-41) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 834-874 mapping at the C-terminus of MCM10 of human origin |
| Modification Notes | The mini-chromosome maintenance (MCM) family of proteins include MCM2, MCM3, MCM4 (Cdc21), MCM5 (Cdc46), MCM6 (Mis5), MCM7 (Cdc47), MCM8, MCM9 and MCM10 (Dna43). The proteins in this family are regulators of DNA replication that act to ensure replication occurs only once in the cell cycle. Expression of MCM proteins increases during cell growth, peaking at G1 to S phase. MCM proteins are crucial components of the pre-replication complex (pre-RC) and are involved in replication fork formation and the recruitment of other DNA replication proteins. The MCM proteins each contain an ATP-binding motif, which is predicted to mediate ATP- dependent opening of double-stranded DNA. MCM proteins are regulated by E2F transcription factors, which induce MCM expression, and by protein kinases, which interact with MCM proteins to maintain the postreplicative state of the cell. MCM10 interacts with replication factors and can interact with MCM2 and MCM6. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of MCM10 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine, porcine and avian: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 834-874 mapping at the C-terminus of MCM10 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 834-874 mapping at the C-terminus of MCM10 of human origin |
| Application Notes | recommended for detection of MCM10 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine, porcine and avian: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
