Application
Western blot analysis of Slac2-a expression in mouse brain tissue extract.| Product Name | Slac2-a Antibody (M-300) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 291-590 mapping at the C-terminus of Slp homologue lacking C2 domains-a of mouse origin |
| Modification Notes | Slac2-a (for synaptotagmin-like protein (Slp) homolog lacking C2 domains-a) links Rab27A on melanosomes with Myosin VA in melanocytes. Slac2-a binds Myosin VA through a C-terminal region and GTP-bound Rab27A through its synaptotagmin-like protein homology domain (SHD), which is located near the N-terminus. The transport of pigment and cytotoxic granules in melanocytes requires the stable formation of this complex, and thus mutations in the binding domains of the three protein components may cause albinism and/or severe immune disorders. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of Slac2-a of mouse, rat and, to a lesser extent, human origin by WB, IP, IF and ELISA: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 291-590 mapping at the C-terminus of Slp homologue lacking C2 domains-a of mouse origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 291-590 mapping at the C-terminus of Slp homologue lacking C2 domains-a of mouse origin |
| Entrez Gene | 79083 |
|---|
Application
Western blot analysis of Slac2-a expression in mouse brain tissue extract.| Application Notes | recommended for detection of Slac2-a of mouse, rat and, to a lesser extent, human origin by WB, IP, IF and ELISA: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
