| Product Name | Sak Antibody (H-288) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | raised against amino acids 671-958 mapping near the C-terminus of Sak of human origin |
| Modification Notes | The Plk (polo-like kinase) family consists of serine/threonine kinases that are closely related to polo and CDC5 proteins, which are required for passage through mitosis in Drosophila and Saccharomyces, respectively. Polo-like kinases, which include Plk, Snk (serum-inducible kinase, also designated Plk2), Fnk (FGF-inducible kinase, also designated Plk3 or PRK) and Sak (also designated Plk4), all play a role in cell proliferation. Sak differs from other polo-like kinases because it has only a single polo box, which forms a dimer fold that resides in the nucleolus, centrosomes, and the cleavage furrow. Sak expression slowly increases during S through M phase, and Sak mediates late mitotic progression, cell survival, and postgastrulation embryonic development. APC/C destroys Sak by proteolysis. Reduced Sak expression causes increased incidence of apoptosis and anaphase arrest, while haploinsufficiency of the Sak gene causes spontaneous tumors to develop, primarily in the liver. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of Sak of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | raised against amino acids 671-958 mapping near the C-terminus of Sak of human origin |
|---|---|
| Tissue Specificity | raised against amino acids 671-958 mapping near the C-terminus of Sak of human origin |
| Entrez Gene | 10733 |
|---|
| Application Notes | recommended for detection of Sak of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
