| Product Name | OAT3 Antibody (H-44) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 199-242 mapping within an internal region of OAT3 of human origin |
| Conjugation | Agarose |
| Modification | Acetylated |
| Modification Notes | The organic anion transporter (OAT) family of proteins mediate the secretion of exogenous and endogenous metabolites from tissues throughout the body. OAT1 (organic anion transporter 1), a 563 amino acid protein, and OAT3 (organic anion transporter 3), a 542 amino acid protein, are two members of the OAT family and are highly expressed in kidneys. Localized specifically to the basolateral membrane, OAT1 and OAT3 are involved in the elimination of toxic organic anions, such as benzylpenicillin and cimetidine, from proximal renal tubules. Via their ability to remove anions from renal tissues, OAT1 and OAT3 are able to regulate the amount of toxins within the kidneys. Additionally, OAT1 functions as an organic anion exchanger that couples the uptake of one organic anion molecule with the efflux of one endogenous dicarboxylic acid molecule, such as ketoglutarate. Four isoforms of OAT1 and three isoforms of OAT3 are expressed due to alternative splicing events. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | ELISAIFIHCIPWB |
| recommended for detection of OAT3 of mouse, rat and human origin by WB, IP, IF and ELISA: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 199-242 mapping within an internal region of OAT3 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 199-242 mapping within an internal region of OAT3 of human origin |
| Application Notes | recommended for detection of OAT3 of mouse, rat and human origin by WB, IP, IF and ELISA: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
