| Modification Notes |
Peroxisomes perform many functions within the eukaryotic cell, including meta-bolism of fatty acids and toxins, importing proteins into organelles and aiding in proliferation. Proliferation of peroxisomes is independent of cell division and can be chemically induced. Pmp34 (34 kDa peroxisomal membrane protein), also known as solute carrier family 25 member 17 (SLC25A17), is a 307 amino acid protein that acts as a as an adenine nucleotide transporter and possibly is involved in the transport of ATP across the peroxisomal membrane. The yeast homolog of Pmp34 participates in peroxisomal proliferation. Pmp34 contains at least two sets of targeting information that results in its insertion into the membrane. Pex19, a protein necessary for early peroxisomal biogenesis, interacts with Pmp34 in the cytosol, and it is suggested that Pex19 may play a key role in Pmp integration into the peroxisomal membrane. |