| Product Name | p-Bcl-3 Antibody (Ser 419) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to phosphorylated Ser 419 of Bcl-3 of human origin |
| Modification | Phosphoralated |
| Modification Notes | On the basis of both functional and structural considerations, members of the IkB family of proteins can be divided into three groups. The first of these groups, IkB-a, includes the avian protein pp40 and the mammalian MAD-3, both of which inhibit binding of p50-p65 NFkB complex or Rel protein to their cognate binding sites but do not inhibit the binding of p50 homodimer to kB sites, suggesting that the IkB-a family binds to the p65 subunit of p50-p65 heterocomplex through ankyrin repeats. The second member of the IkB family is represented by a protein designated IkB-b. The third group of IkB proteins is represented by IkB-g, a protein identical in sequence with the C-terminal domain of the p110 precursor of NFkB p50 and expressed predominantly in lymphoid cells. The proto-oncogene Bcl-3, believed to be involved in certain human B cell leukemias, encodes a protein that functions as an IkB-like molecule for native NFkB but is specific for the p50 subunit. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIFELISA |
| recommended for detection of Ser 419 of mouse and human origin by WB, IF and ELISA: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to phosphorylated Ser 419 of Bcl-3 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to phosphorylated Ser 419 of Bcl-3 of human origin |
| Entrez Gene | 602 |
|---|
| Application Notes | recommended for detection of Ser 419 of mouse and human origin by WB, IF and ELISA: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
