| Product Name | BS69 Antibody (H-265) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 255-519 mapping near the C-terminus of BS69 of human origin |
| Modification Notes | The adenovirus E1A gene products are nuclear phosphoproteins with the ability to transactivate other adenovirus genes. BS69 specifically interacts with adenovirus 5 E1A and inhibits transactivation by the 289R E1A protein. BS69 interacts with the co-repressor N-CoR through an essential MYND domain in the carboxy terminus of N-CoR (2). BS69 also inhibits the transcriptional activity of c-Myb (3). During oncogenesis, this BS69/Myb regulatory circuit maybe be a target for disruption (3). Another ubiquitously expressed member of the Myb gene family, b-Myb, also interacts with BS69 and N-CoR to function as a transcriptional repressor (4). BRAM1, a splice variant of BS69, binds specifically to bone morphogenetic protein type IA receptor (BMPR-IA). BRAM1 localizes to the cytoplasm of mammalian cells, while BS69 localizes to the cell nucleus (5). Unlike BS69, BRAM1 is unable to repress transcription (2). |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of BS69 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine, porcine and avian: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 255-519 mapping near the C-terminus of BS69 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 255-519 mapping near the C-terminus of BS69 of human origin |
| Entrez Gene | 10771 |
|---|
| Application Notes | recommended for detection of BS69 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine, porcine and avian: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
