Application
Western blot analysis of α T-catenin expression in Hep G2 (A) and A-10 (B) whole cell lysates and human heart tissue extract (C).| Product Name | α T-catenin Antibody (H-65) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 61-125 mapping near the N-terminus of α T-catenin of human origin |
| Modification Notes | The catenins (å, ∫, © and ∂) are ubiquitously expressed, cytoplasmic proteins that associate with E-cadherin at cellular junctions. Catenin/cadherin complexes play an important role in mediating cellular adhesion. å T-catenin, also referred to as VR22, is a 895-amino acid protein that is most abundantally expressed in cardiomyocytes and in the peritubular myoid cells of the testis. å T-catenin binds to å E-catenin as well as to ∫-catenin, and it functions to inhibit Wnt signaling. CTNNA3, the gene that encodes for å-T-catenin, is located on chromosome 10, and mutations in this gene show a strong correlation to late-onset Alzheimer's disease (LOAD) as well as to dilated cardiomyopathy. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of α T-catenin of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 61-125 mapping near the N-terminus of &alpha T-catenin of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 61-125 mapping near the N-terminus of α T-catenin of human origin |
| Entrez Gene | 29119 |
|---|
Application
Western blot analysis of α T-catenin expression in Hep G2 (A) and A-10 (B) whole cell lysates and human heart tissue extract (C).| Application Notes | recommended for detection of α T-catenin of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
