Application
Western blot analysis of CHMP1B expression in non-transfected 293T: (A), mouse CHMP1B transfected 293T: (B) and HeLa (C) whole cell lysates and mouse thyroid tissue extract (D).| Product Name | CHMP1B Antibody (C-20) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope mapping near the C-terminus of CHMP1B of human origin |
| Modification Notes | The charged multivesicular body proteins or chromatin modifying proteins, commonly designated CHMPs, belong to the vacuolar sorting protein family and function as chromatin-modifying proteins. CHMP1-6 are all components of ESCRT (endosomal sorting complex required for transport) I, II or III complexes. These complexes are crucial for sorting endosomal articles into multivesicular bodies (MVBs), and are also required for the formation of these bodies. CHMP1 interacts with VPS4B and localizes to early endosomes. Two isoforms, encoded by distinct genes, exist for CHMP1. They are designated CHMP1A and CHMP1B. CHMP1 overexpression can lead to the dilation of endosomal compartments resulting in a disruption of the normal distribution of endosomal markers. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of CHMP1B of mouse, rat and human origin by WB, IP, IF and ELISA also recommended for detection of 2610002M06Rik of mouse origin also reactive with additional species, including equine, canine, bovine, porcine and avian: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope mapping near the C-terminus of CHMP1B of human origin |
|---|---|
| Tissue Specificity | epitope mapping near the C-terminus of CHMP1B of human origin |
| Entrez Gene | 57132 |
|---|
Application
Western blot analysis of CHMP1B expression in non-transfected 293T: (A), mouse CHMP1B transfected 293T: (B) and HeLa (C) whole cell lysates and mouse thyroid tissue extract (D).| Application Notes | recommended for detection of CHMP1B of mouse, rat and human origin by WB, IP, IF and ELISA also recommended for detection of 2610002M06Rik of mouse origin also reactive with additional species, including equine, canine, bovine, porcine and avian: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
