| Product Name | TdTIF1 Antibody (H-72) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 228-297 mapping near the C-terminus of TdTIF1 of human origin |
| Modification Notes | Terminal deoxynucleotidyltransferase (TdT) is a DNA polymerase which catalyzes the addition of deoxyribonucleotides onto the 3'-hydroxyl end of DNA primers without a DNA template. TdT activity can be positively or negatively regulated by association with certain TdT-interacting factors. TdTIF1 (Terminal deoxynucleotidyltransferase-interacting factor 1), also called DNTTIP1 or TdIF1, localizes to the nucleus and functions to repress TdT activity. In vitro, TdTIF1 binds to the Pol ∫-like region of TdT, thus masking its DNA-binding region and blocking its access to the DNA. Expressed throughout the body with highest expression in the thymus, TdTIF1 contains N-terminal AT-hook motifs through which it binds to TdT. In addition to inhibiting TdT-DNA interaction, TdTIF1 can bind to TReP-132, a transcriptional co-activator of steroidogenic factor 1 (SF-1). When bound to SF-1, TdTIF1 enhances gene expression in steroid-producing cells. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of TdTIF1 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 228-297 mapping near the C-terminus of TdTIF1 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 228-297 mapping near the C-terminus of TdTIF1 of human origin |
| Entrez Gene | 116092 |
|---|
| Application Notes | recommended for detection of TdTIF1 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
