Application
Western blot analysis of CASC3 expression in non-transfected: (A) and human CASC3 transfected: (B) 293T whole cell lysates.| Product Name | CASC3 Antibody (H-190) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 451-640 mapping near the C-terminus of CASC3 of human origin |
| Modification Notes | CASC3 (cancer susceptibility candidate 3), also known as BTZ or MLN51, is a 703 amino acid protein that localizes to both the nucleus and the cytoplasm and contains a coiled coil domain. Expressed in a variety of tissues, CASC3 functions as a component of the exon junction complex (EJC), a multi-protein structure that exists on spliced mRNAs and plays a role in nonsense-mediated mRNA decay at exon-exon junctions. As a component of the EJC, CASC3 is thought to participate in mRNA modification and may also be involved in mRNA transport and ribonucleoprotein particle function. CASC3 is overexpressed in breast and gastric cancers, suggesting a role for CASC3 in tumor development and metastasis. The gene encoding CASC3 maps to human chromosome 17, which comprises over 2.5% of the human genome and encodes over 1,200 genes. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of CASC3 of mouse, rat and human origin by WB, IP, IF and ELISA: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 451-640 mapping near the C-terminus of CASC3 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 451-640 mapping near the C-terminus of CASC3 of human origin |
| Entrez Gene | 22794 |
|---|
Application
Western blot analysis of CASC3 expression in non-transfected: (A) and human CASC3 transfected: (B) 293T whole cell lysates.| Application Notes | recommended for detection of CASC3 of mouse, rat and human origin by WB, IP, IF and ELISA: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
