Application
Western blot analysis of FBXO17 expression in mouse brain tissue extract.| Product Name | FBXO17 Antibody (H-40) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 103-142 mapping within an internal region of FBXO17 of human origin |
| Modification Notes | F-box (FBX) proteins are critical components of the SCF (Skp1-CUL-1-F-box protein) type E3 ubiquitin ligase complex and are involved in substrate recognition and recruitment for ubiquitination. FBXs are members of a larger family of proteins that are involved in the regulation of a wide variety of cellular processes (including the cell cycle, immune responses, signaling cascades and developmental events) through the targeting of proteins, such as cyclins, cyclin-dependent kinase inhibitors, I˚B-å and ∫-catenin, for proteasomal degradation. FBXO17 (F-box only protein 17), also known as FBG4, FBX17, FBX26 or FBXO26, is a 278 amino acid protein that contains one F-box domain and one F-box associated domain. Expressed in kidney, heart, liver, skeletal muscle, brain and spleen, FBXO17 functions as a substrate-recognition component of of the SCF complex and directly interacts with Skp1 p19 and CUL-1. Multiple isoforms of FBXO17 exist due to alternative splicing events. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of FBXO17 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including canine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 103-142 mapping within an internal region of FBXO17 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 103-142 mapping within an internal region of FBXO17 of human origin |
| Entrez Gene | 115290 |
|---|
Application
Western blot analysis of FBXO17 expression in mouse brain tissue extract.| Application Notes | recommended for detection of FBXO17 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including canine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
