| Modification Notes |
RBPMS (RNA binding protein with multiple splicing), also known as HERMES, is a 196 amino acid protein that contains one RRM (RNA recognition motif) domain and belongs to the RRM family of RNA-binding proteins. Expressed ubiquitously, RBPMS exists as multiple alternatively spliced isoforms and is thought to bind RNA, possibly playing a role in RNA-related events, such as transcription and translation. The gene encoding RBPMS maps to human chromosome 8, which consists of nearly 146 million base pairs, houses more than 800 genes and is associated with a variety of diseases and malignancies. Schizophrenia, bipolar disorder, Trisomy 8, Pfeiffer syndrome, congenital hypothyroidism, Waardenburg syndrome and some leukemias and lymphomas are thought to occur as a result of defects in specific genes that map to chromosome 8. |