| Product Name | Rim4 Antibody (C-18) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope mapping near the C-terminus of Rim4 of human origin |
| Modification Notes | Rab 3, a neural/neuroendocrine-specific member of the Rab family, is involved in Ca2+-regulated exocytosis. Rab 3 functions in an inhibitory capacity by controlling the recruitment of secretory vesicles into a releasable pool at the plasma membrane. Rim (Rab 3 interacting molecule), a putative effector protein for Rab 3 proteins, is thought to regulate neutrotransmitter release through its interaction with Rab 3 and other synaptic proteins. The mammalian genome contains four Rim genes that encode six forms of Rim: Rim1å, 2å, 2∫, 2©, 3© and 4©. Rim1å and 2å are composed of an N-terminal zinc finger, which contains the Rab 3 binding site, a central PDZ domain and two C-terminal C2 domains. Rim2∫ is nearly identical to Rim2å, with the exception of an N-terminal zinc-finger region which Rim2∫ lacks. Rim2©, 3© and 4© lack the N-terminal zinc finger and PDZ domain, and consist of only the C-terminal C2 domain with neighboring sequences. Rim4 (Rab 3 interacting molecule 4), also known as Rim4© or regulating synaptic membrane exocytosis protein 4, is a 269 amino acid protein that localizes to the cell junction and regulates synaptic membrane exocytosis. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIFELISA |
| recommended for detection of Rim4 of mouse, rat and human origin by WB, IF and ELISA non cross-reactive with RIM1 and RIM2 also reactive with additional species, including equine, canine, bovine, porcine and avian: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope mapping near the C-terminus of Rim4 of human origin |
|---|---|
| Tissue Specificity | epitope mapping near the C-terminus of Rim4 of human origin |
| Entrez Gene | 140730 |
|---|
| Application Notes | recommended for detection of Rim4 of mouse, rat and human origin by WB, IF and ELISA non cross-reactive with RIM1 and RIM2 also reactive with additional species, including equine, canine, bovine, porcine and avian: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
