Application
Western blot analysis of MARCO expression in non-transfected: (A) and human MARCO transfected: (B) 293T whole cell lysates.| Product Name | MARCO Antibody (H-50) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 198-247 mapping within an extracellular domain of MARCO of human origin |
| Modification Notes | Macrophages provide their host with a nonspecific immune defense against pathogens. One cellular surface receptor utilized by macrophages is the macrophage receptor with collagenous structure (MARCO). MARCO is a member of the class A scavenger receptor molecules. This single-pass type II membrane protein was first identified in subpopulations of murine macrophages in the spleen and medullary cord of lymph nodes. MARCO is additionally found in increased levels in other tissues during bacterial infection. MARCO is a major receptor in alveolar macrophages, binding both Gram-positive and Gram-negative bacteria. Additionally, MARCO has been shown to be the major scavenger receptor involved in silica uptake and cytotoxicity in murine macrophages. In mice, mutations in the gene coding for MARCO may lead to increased pulmonary inflammation and cytokine release as well as an imparied ability to clear bacteria from the lungs. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of Macrophage receptor MARCO of mouse, rat and human origin by WB, IP, IF and ELISA: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 198-247 mapping within an extracellular domain of MARCO of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 198-247 mapping within an extracellular domain of MARCO of human origin |
| Entrez Gene | 8685 |
|---|
Application
Western blot analysis of MARCO expression in non-transfected: (A) and human MARCO transfected: (B) 293T whole cell lysates.| Application Notes | recommended for detection of Macrophage receptor MARCO of mouse, rat and human origin by WB, IP, IF and ELISA: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
