| Product Name | ITF Antibody (D-13) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope mapping within an internal region of ITF of human origin |
| Modification Notes | Trefoil peptides are protease resistant molecules secreted throughout the gut that play a role in mucosal healing. Trefoil peptides contain three intrachain disulfide bonds, forming the trefoil motif, or P-domain. ITF (intestinal trefoil factor) is expressed in the epithelial mucosal layer of the small intestine and colon, brain and pituitary. SP (also known as pancreatic trefoil factor 2 or pancreatic spasmolytic polypeptide) is an inhibitor of spasmolytic activity and gastric acid secretion. Human SP is expressed exclusively in normal stomach epithelium and unlike pS2, it is not expressed in breast carcinoma. Both SP and ITF are predominantly found in gastrointestinal tissues, and are upregulated around areas of epithelial damage and in meta- and neoplasia. The genes which encode pS2, SP and ITF are clustered in human chromosome 21q22.3. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of ITF of human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, bovine and porcine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope mapping within an internal region of ITF of human origin |
|---|---|
| Tissue Specificity | epitope mapping within an internal region of ITF of human origin |
| Entrez Gene | 7033 |
|---|
| Application Notes | recommended for detection of ITF of human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, bovine and porcine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
