Application
Western blot analysis of WDR4 expression in non-transfected: (A) and mouse WDR4 transfected: (B) 293T whole cell lysates.| Product Name | WDR4 Antibody (S-20) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope mapping within an internal region of WDR4 of human origin |
| Modification Notes | WD-repeats are motifs that are found in a variety of proteins and are characterized by a conserved core of 40-60 amino acids that commonly form a tertiary propeller structure. While proteins that contain WD-repeats participate in a wide range of cellular functions, they are generally involved in regulatory mechanisms concerning chromatin assembly, cell cycle control, signal transduction, RNA processing, apoptosis and vesicular trafficking. WDR4 (WD-repeat-containing protein 4), also known as TRM82, is a 412 amino acid protein that contains two WD-repeats. Expressed as multiple isoforms due to alternative splicing events, WDR4 forms a complex with METTL1 (methyltransferase like 1) that is necessary for the 7-methylguanosine modification of tRNA. Defects in the gene encoding WDR4 may be associated with the development of Down syndrome, a chromosomal disorder characterized by deformed physical features and mental retardation. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of WDR4 of mouse, rat and human origin by WB, IP, IF and ELISA non cross-reactive with family member WDR5 also reactive with additional species, including equine, bovine and porcine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope mapping within an internal region of WDR4 of human origin |
|---|---|
| Tissue Specificity | epitope mapping within an internal region of WDR4 of human origin |
| Entrez Gene | 10785 |
|---|
Application
Western blot analysis of WDR4 expression in non-transfected: (A) and mouse WDR4 transfected: (B) 293T whole cell lysates.| Application Notes | recommended for detection of WDR4 of mouse, rat and human origin by WB, IP, IF and ELISA non cross-reactive with family member WDR5 also reactive with additional species, including equine, bovine and porcine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
