Application
Immunoperoxidase staining of human adrenal gland tissue showing cytoplasmic staining of glandular cells.Application
Western blot analysis of NMDAε4 expression in IMR-32 whole cell lysate.| Product Name | NMDAε4 Antibody (H-119) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 268-386 mapping to an internal region glutamate (NMDA) receptor epsilon 4 of human origin |
| Modification Notes | Glutamate receptors mediate most excitatory neurotransmission in the brain and play an important role in neural plasticity, neural development and neurodegeneration. Ionotropic glutamate receptors are categorized into NMDA receptors and kainate/AMPA receptors, both of which contain glutamate-gated, cation-specific ion channels. Kainate/AMPA receptors are co-localized with NMDA receptors in many synapses and consist of seven structurally related subunits designated GluR-1 to -7. The kainate/AMPA receptors are primarily responsible for fast excitatory neurotransmission by glutamate, whereas the NMDA receptors exhibit slow kinesis of Ca2+ ions and a high permeability for Ca2+ ions. The NMDA receptors consist of five subunits: é 1, 2, 3, 4 and one Ω subunit. The Ω subunit is expressed throughout the brainstem whereas the four epsilon subunits display limited distribution. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFIHCELISA |
| recommended for detection of the glutamate (NMDA) receptor epsilon 4 subtype of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA also reactive with additional species, including canine, bovine and porcine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 268-386 mapping to an internal region glutamate (NMDA) receptor epsilon 4 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 268-386 mapping to an internal region glutamate (NMDA) receptor epsilon 4 of human origin |
| Entrez Gene | 2906 |
|---|
Application
Immunoperoxidase staining of human adrenal gland tissue showing cytoplasmic staining of glandular cells.
Application
Western blot analysis of NMDAε4 expression in IMR-32 whole cell lysate.| Application Notes | recommended for detection of the glutamate (NMDA) receptor epsilon 4 subtype of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA also reactive with additional species, including canine, bovine and porcine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
