Application
Western blot analysis of SLC35C1 expression in human esophagus tissue extract.Application
Western blot analysis of SLC35C1 expression in Jurkat (A) and CCRF-CEM (B) whole cell lysates.Application
Western blot analysis of SLC35C1 expression in Jurkat whole cell lysate.| Product Name | SLC35C1 Antibody (A-20) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | raised against SLC35C1 of human origin |
| Modification Notes | SLC35C1 (solute carrier family 35, member C1), also known as FUCT1 (GDP-fucose transporter 1), is a multi-pass membrane protein that belongs to the SLC35C subfamily of the Nucleotide-Sugar Transporter (NST) family. Members of the NST family are transmembrane proteins that mediate the translocation of nucleotide-sugars from the cytosol to the interior lumen of the endoplasmic reticulum (ER) and the golgi apparatus via an antiport mechanism, exchanging nucleoside monophosphates for nucleotide-sugars. This activity of NSTs is important for providing an available source of nucleotide-sugars for glycoconjugate synthesis. Localizing to the golgi apparatus membrane, SLC35C1 participates in the transport of GDP-fucose from the cytoplasm into the golgi lumen. Mutations in the gene encoding SLC35C1 are associated with CDG2C (congenital disorder of glycosylation type 2C), also known as LAD2 (leukocyte adhesion deficiency type II). CDG2C is characterized by the lack of fucosylated glycoproteins and symptoms include short stature, mental retardation, elevated peripheral leukocytes and facial stigmata. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPELISA |
| recommended for detection of SLC35C1 of human origin by WB, IP and ELISA: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | raised against SLC35C1 of human origin |
|---|---|
| Tissue Specificity | raised against SLC35C1 of human origin |
| Entrez Gene | 55343 |
|---|
Application
Western blot analysis of SLC35C1 expression in human esophagus tissue extract.
Application
Western blot analysis of SLC35C1 expression in Jurkat (A) and CCRF-CEM (B) whole cell lysates.
Application
Western blot analysis of SLC35C1 expression in Jurkat whole cell lysate.| Application Notes | recommended for detection of SLC35C1 of human origin by WB, IP and ELISA: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
