| Product Name | lacritin Antibody (G-14) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope mapping within an extracellular domain of lacritin of human origin |
| Modification Notes | The lacrimal functional unit (LFU) is an integrated system consisting of lacrimal glands, ocular surface glands (cornea, conjunctiva and meibomian glands), eyelids and associated sensory and motor nerves. The LFU maintains a healthy ocular surface primarily through a properly functioning tear film that provides protection, lubrication and an environment for corneal epithelial cell renewal. LFU cells express thousands of proteins inlcuding lacritin. Lacritin, also known as LACRT, is a 138 amino acid secreted protein that is expressed in secretory granules of many acinar cells in lacrimal gland and in scattered acinar cells of salivary glands. Considered a novel LFU-specific growth factor and glycoprotein in human tears, lacritin flows through ducts to target corneal epithelial cells on the ocular surface and promotes basal tear peroxidase secretion. Downregulation of lacritin leads to blepharitis and other dry eye syndromes. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIFELISA |
| recommended for detection of lacritin of human origin by WB, IF and ELISA: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope mapping within an extracellular domain of lacritin of human origin |
|---|---|
| Tissue Specificity | epitope mapping within an extracellular domain of lacritin of human origin |
| Entrez Gene | 90070 |
|---|
| Application Notes | recommended for detection of lacritin of human origin by WB, IF and ELISA: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
