Application
Western blot analysis of GPR91 expression in Caki-1 whole cell lysate.| Product Name | GPR91 Antibody (H-80) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 86-165 mapping within an internal region of GPR91 of human origin |
| Modification Notes | GPR91 (formerly known as P2U2 ) is a G protein-coupled, dicarboxylic acid succinate receptor. It has a high level of expression in the kidney, predominantly in the proximal tubules, and localizes to the plasma membrane. It has also been found at low levels in the liver and the spleen. GPR91 functions as a citric acid cycle intermediate succinate receptor. Two signaling pathways result from GPR91 activation, the pertussis-toxin-sensitive Gi/Go pathway and the pertussis-toxin-insensitive Gq pathway. Four amino acid residues are necessary for GPR91 activation by succinate, Arg 99, His 103, Arg 252, and Arg 281. GPR91 plays an important role in the succinate-induced hypertensive effect and may be involved in renovascular hypertension, a disease linked to diabetes, renal failure, and atherosclerosis. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of GPR91 of mouse, rat and human origin by WB, IP, IF and ELISA: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 86-165 mapping within an internal region of GPR91 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 86-165 mapping within an internal region of GPR91 of human origin |
| Entrez Gene | 56670 |
|---|
Application
Western blot analysis of GPR91 expression in Caki-1 whole cell lysate.| Application Notes | recommended for detection of GPR91 of mouse, rat and human origin by WB, IP, IF and ELISA: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
