| Product Name | Sec61α Antibody (H-296) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 181-476 of Sec61α1 of human origin |
| Conjugation | Agarose |
| Modification | Acetylated |
| Modification Notes | In mammalian cells, protein translocation across the endoplasmic reticulum (ER) membrane is almost exclusively co-translational (1). This transport depends on the Sec61 complex, which is homologous to the yeast Sec61p complex and has been identified in mammals as a ribosome-bound pore-forming membrane protein complex (1,2). The Sec61 complex associates with two ubiquitous ER membrane proteins Sec62 (also designated human translocation protein 1 or HTP1) and Sec63 (1-3). The Sec61 complex forms the hydrophilic pore in the membrane through which the nascent polypeptide is translocated (4-7). Sec61p seems to be the evolutionary conserved component since homologues of Sec61p have been found both in bacteria and mammals (1,2). Sec62 is expressed in various human tissues such as the heart, brain, placenta, liver and pancreas (2). |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | ELISAIFIPWB |
| WB:1:100~1:400 IP:1:20~1:100 IF:1:20~1:100 |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 181-476 of Sec61α1 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 181-476 of Sec61α1 of human origin |
| Entrez Gene | 29927 |
|---|
| Application Notes | WB:1:100~1:400 IP:1:20~1:100 IF:1:20~1:100 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
