| Product Name | VAMP-4 Antibody (H-65) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 61-125 mapping within an internal region of VAMP-4 of human origin |
| Modification Notes | Vesicle-associated membrane protein 4 (VAMP-4) belongs to a subfamily of the large SNARE family. VAMP-4 is distributed mainly in tubular and vesicular membranes of the trans-Golgi network, particularly in heart, brain and testis, but is found in almost all tissues. VAMP-4 interacts with small synaptic vesicles and Clathrin-coated vesicles, participating in intracellular trafficking of secreted and membrane-associated proteins. It forms a complex with the TGN-trafficking protein syntaxin 6. VAMP-4 contains a di-leucine motif which binds to the adaptor protein-1 (AP-1) subunit µ-1a. Phosphorylation-dependent binding of the molecule PACS-1 to AP-1 modulates the attachment of AP-1 to VAMP-4. VAMP-4 may contribute to risk for suicide attempt, possibly through alterations in neural conduction. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of VAMP_4 isoforms 1 and 2 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 61-125 mapping within an internal region of VAMP-4 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 61-125 mapping within an internal region of VAMP-4 of human origin |
| Application Notes | recommended for detection of VAMP_4 isoforms 1 and 2 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
